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SAN JOSE, Calif. — Top-seed Andy Roddick easily defeated Japanese teen star Kei Nishikori 6-2, 6-4 to advance to to the quarterfinals of the SAP Open.

James Blake also advanced, overcoming first-serve problems to beat Jesse Levine 6-3, 6-4. Earlier, John Isner beat third-seeded Tommy Haas 4-6, 7-6 (6), 6-3, No. 5 Mardy Fish got past Denis Gremelmayr 6-7 (4), 6-3, 6-3, and Lu Yen-hsun beat Wayne Odesnik 6-4, 6-4.

Copa Telmex: Sixth-seeded Igor Andreev beat Jiri Vanek 6-1, 0-6, 6-4 to reach the Copa Telmex quarterfinals in Buenos Aires, Argentina. Andreev will face Jose Acasuso, a 6-3, 6-4 winner over Daniel Gimeno Traver.

Also, eighth-seeded Filippo Volandri defeated Sergio Roitman 7-5, 7-5 to set up a match against Agustin Calleri, a 3-6, 6-2, 6-2 winner over Luis Horna.

Nadal falls in upset: Top-seeded Rafael Nadal lost to Andreas Seppi of Italy 3-6, 6-3, 6-4 on a day of upsets, leaving the ABN Amro without seeded players entering the quarterfinals.

Beaten earlier in the day were second-seeded Nikolay Davydenko of Russia, third-seeded David Ferrer of Spain and fifth-seeded Tomas Berdych of the Czech Republic. It is only the third time since 2000 no seeded players are in the quarters of an ATP tournament. It previously happened in 2006 in Nottingham, England, and in 2002 in Buenos Aires, Argentina.

Sharapova rolls on: Australian Open champion Maria Sharapova reached the Qatar Open quarterfinals with a 6-2, 6-2 victory over Tamarine Tanasugarn. The fourth-seeded Sharapova will play Caroline Wozniakci, who ousted Anabel Medina Garrigues 3-6, 7-6 (3), 6-3.

Second-seeded Svetlana Kuznetsova was upset by Sybille Bammer, 6-3, 7-6 (8), and sixth-seeded Venus Williams lost to Dominika Cibulkova 6-3, 6-3. Also, third-seeded Jelena Jankovic beat Ai Sugiyama 6-1, 6-2 and will play Li Na, who defeated 12th-seeded Shahar Peer 6-1, 6-3. Vera Zvonareva topped 11th-seeded Dinara Safina 7-5, 6-3.